Mucin-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Mucin-1

Mucin-1 Definition

Expressed as alternative isoforms in some hematopoietic cells and most glandular and ductal epithelial cells by human MUC1 Gene, highly glycosylated Mucin-1 is a type I membrane protein (major form) containing a large extracellular tandem repeat domain and a SEA domain. The number of repeats is highly polymorphic. MUC1 may protect epithelial surfaces, play a role in adhesion, cell-cell interactions, signaling, and metastasis. MUC1 may interact directly or indirectly with the actin cytoskeleton. Isoforms 5 and 9 are secreted. Isoform 7 behaves as a receptor and binds isoform 5; binding induces phosphorylation of isoform 7, alters cell morphology, and initiates cell signaling. MUC1 can bind to GRB2. Cleaved isoform 1 forms a heterodimer with its secreted C-terminal peptide. Isoforms 1 and 7 are transphosphorylated on serine and tyrosine residues.

Mucin-1 Synonyms

Mucin 1, Breast Carcinoma-Associated Antigen DF3, CD227, CD227 Antigen, Carcinoma-Associated Mucin, DF3 Antigen, EMA, Episialin, Epithelial Membrane Antigen, H23 Antigen, H23AG, MUC1, Mucin, PEM, PEMT, PUM, Peanut-Reactive Urinary Mucin, Polymorphic Epithelial Mucin, Transmembrane Mucin 1, Tumor-Associated Epithelial Membrane Antigen, Tumor-Associated Mucin

Mucin-1

Mucin-1 Definition

Mucin-1 Synonyms

Terms in Mucin-1 category