Musculin
Cancer Terms ->
Gene Product ->
Protein ->
Protein Organized by Function ->
Regulatory Protein ->
Transcription Regulatory Protein ->
Transcription Factor -> Musculin
Musculin Definition
The predicted 218-amino acid protein contains a bHLH motif, a putative nuclear localization signal, a glycine-rich region, and a stretch of acidic residues. MSC is capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro, and forms heterodimers with E2A proteins in vivo. MSC contains a transcriptional repression domain and is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. MSC is a downstream target of the B-cell receptor signal transduction pathway. Mice engineered to lack the protein lack muscle structures derived from the first brachial arch. (from LocusLink and OMIM)
Musculin Synonyms
Musculin, Activated B-cell Factor-1, MSC, Myogenic Repressor
Terms in Musculin category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.