Myosin Light Polypeptide Kinase
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Myosin Light Polypeptide Kinase Definition
Myosin Light Polypeptide Kinase, encoded by the MYLK gene, is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the other arm of chromosome 3. Seven transcript variants that produce seven isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. (from LocusLink)
Myosin Light Polypeptide Kinase Synonyms
Myosin Light Polypeptide Kinase, EC 2.7.1.117, MLC Kinase, MLCK, MYLK, MYLK2, Myosin Light Chain Kinase, Myosin Light Chain Kinase, Smooth Muscle and Non-Muscle Isozymes, Myosin light chain kinase 2, skeletal/cardiac muscle, Myosin, Light Polypeptide Kinase
Terms in Myosin Light Polypeptide Kinase category
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