Cancer Terms

NF-IB Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Factor -> NF-I -> NF-IB Protein

NF-IB Protein Definition

Expressed as 3 alternative isoforms by human NFIB Gene (CTF/NF-I Family), nuclear NF-IB Protein contains an N-terminal DNA-binding domain, a C-terminal transactivation domain, and a DWA/MH1 domain. NF-IB binds TTGGCNNNNNGCCAA DNA palindromes in viral and cellular promoters as a homodimeric factor capable of activating transcription and replication. Truncated 188-aa NFIB3 protein contains only the N-terminal DNA-binding domain, forms heterodimers with other NFI proteins, reduces their ability to bind DNA, and may repress transcription by other NFI proteins. (NCI)

NF-IB Protein Synonyms

NF-IB Protein, CCAAT-Box Binding Transcription Factor, CTF, NF-I/B, NF-IB, NF1-B, NFI-B, NFI-RED, NFIB, NFIB2, NFIB3, Nuclear Factor 1 B-Type, Nuclear Factor I/B, TGGCA-Binding Protein

Terms in NF-IB Protein category



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