NR1 Protein
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NR1 Protein Definition
Broadly expressed by human NR1 Gene (FNR Family), 597-aa 67-kDa cytoplasmic NADPH-Dependent FMN and FAD Containing Oxidoreductase is an enzyme homologous to cytochrome P-450 reductase that binds FMN, FAD, and NADPH cofactors, reduces cytochrome c, and metabolizes electron acceptors doxorubicin, menadione, and potassium ferricyanide. NR1 shares 41 to 44% similarity with nitric oxide synthase-2, methionine synthase transferase, and P-450 reductase. It may play a role in metabolic activation of bioreductive anticancer drugs and other chemicals activated by 1-electron reduction. (NCI)
NR1 Protein Synonyms
NADPH Dependent Diflavin Oxidoreductase 1, NADPH-Dependent FMN and FAD Containing Oxidoreductase, NDOR1, NR1
Terms in NR1 Protein category
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