Nanoparticle Albumin-Bound Rapamycin
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Nanoparticle Albumin-Bound Rapamycin Definition
The macrolide antibiotic rapamycin bound to nanoparticle albumin with immunosuppressant and potential antiangiogenic and antineoplastic activities. Rapamycin (sirolimus) binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate a complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. In turn, inhibition of mTOR may result in the inhibition of the phosphatidylinositol 3 (PI-3) kinase/Akt pathway and vascular endothelial cell growth factor (VEGF) secretion, which may result in decreased tumor cell proliferation and tumor angiogenesis. The binding of water-insoluble rapamycin to nanoparticle albumin permits the albumin-mediated endocytosis of rapamycin by tumor cells and endothelial cells.
Nanoparticle Albumin-Bound Rapamycin Synonyms
Nanoparticle Albumin-Bound Rapamycin, ABI-009, Nab-Rapamycin
Terms in Nanoparticle Albumin-Bound Rapamycin category
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