Neuro-Oncological Ventral Antigen-2
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RNA Binding Protein -> Neuro-Oncological Ventral Antigen-2
Neuro-Oncological Ventral Antigen-2 Definition
Expressed in brain by human NOVA2 Gene, RNA-binding NOVA2 protein is recognized by the paraneoplastic syndrome antibody anti-Ri. NOVA1 and NOVA2 bind to similar RNA ligands with high affinity and may regulate RNA splicing. The NOVA2 KH3 domain interacts with single-stranded RNA; KH3 bound to stem loop RNA resembles a vise, with UCAC held between an invariant Gly-X-X-Gly motif and a variable loop. Tetranucleotide recognition is supported by an aliphatic alpha-helix/beta-sheet RNA-binding platform that mimics UG by making Watson-Crick-like hydrogen bonds with CA. (NCI)
Neuro-Oncological Ventral Antigen-2 Synonyms
Neuro-Oncological Ventral Antigen 2, ANOVA, NOVA2, NOVA3, Neuro-Oncological Ventral Antigen 3
Terms in Neuro-Oncological Ventral Antigen-2 category
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