Neuronal-SHC Protein
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Neuronal-SHC Protein Definition
Expressed in the brain by human SHC3 Gene, the 474-aa 52-kD and 594-aa 64-kD isoforms of Neuronal SHC are similar to SHC; nearly 70% homology in the PTB and SH2 domains. SHC3 appears involved in signaling from BDNF/TRKB to the RAS/MAPK pathway. BDNF induces tyrosine phosphorylation of SHC3 and binding to TRKB. Activated EGFR also interacts with and tyrosine-phosphorylates SHC3, inducing an association with GRB2. SHC3 and SCK mediate EGF signaling, but SHC3 has a higher affinity for TRKA and TRKB. (NCI)
Neuronal-SHC Protein Synonyms
Neuronal SHC, NSHC, Neuronal SHC-Like Protein, SHC3, SHCC, SRC Homology 2 Domain Containing Transforming Protein C3
Terms in Neuronal-SHC Protein category
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