Neurotrophic Tyrosine Kinase Receptor Type-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Receptor Tyrosine Kinase -> Neurotrophic Tyrosine Kinase Receptor Type-1

Neurotrophic Tyrosine Kinase Receptor Type-1 Definition

Human NTRK1 Gene (TKRI/INSR Family) encodes neuronal TRKA-I and non-neural TRKA-II isoforms (similar biological properties) of type I membrane protein Neurotrophic Tyrosine Kinase Receptor Type 1, containing 2 LRR repeats and 2 Ig-like C2-type domains. NTRK1 exists in dynamic equilibrium as low affinity monomers and high affinity dimers with TRKA, TRKB, or TRKC to bind NGF, NTF3, NTF4/5, and BDNF neurotrophins that regulate development and function of the nociceptive and thermoregulatory nervous systems. Ligand stimulation of TRK activates autophosphorylation, SHC, PI-3 kinase, PLC-gamma-1, and ERK1 signaling pathways. NTRK1 defects cause CIPA. Chromosomal rearrangements of NTRK1 fused to TPM3 or to TFG in t(1;3)(q21;q11) are associated with papillary thyroid carcinoma. (NCI)

Neurotrophic Tyrosine Kinase Receptor Type-1 Synonyms

Neurotrophic Tyrosine Kinase Receptor Type 1, NTRK1, Nerve Growth Factor Receptor Type 1

Neurotrophic Tyrosine Kinase Receptor Type-1

Neurotrophic Tyrosine Kinase Receptor Type-1 Definition

Neurotrophic Tyrosine Kinase Receptor Type-1 Synonyms

Terms in Neurotrophic Tyrosine Kinase Receptor Type-1 category