Neurotrophic Tyrosine Kinase Receptor Type-3
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Receptor Tyrosine Kinase -> Neurotrophic Tyrosine Kinase Receptor Type-3
Neurotrophic Tyrosine Kinase Receptor Type-3 Definition
Widely expressed (mainly nervous tissue) by human NTRK3 Gene (IR Tyr Kinase Family) as alternative isoforms A (839-aa 94-kDa precursor), B (612-aa), C (825-aa), and D (830-aa), Neurotrophic Tyrosine Kinase Receptor Type 3 is a type I membrane receptor for NTF3 containing 2 LRR repeats and 2 Ig-like C2-type domains. Monomeric (low affinity) and dimeric (high affinity) forms appear to exist in dynamic equilibrium and the isoforms do not have identical signaling properties. Known substrates for TRK receptors are SHC, PI-3 kinase, and PLC-gamma-1. NTRK3 undergoes ligand-mediated auto-phosphorylation. (NCI)
Neurotrophic Tyrosine Kinase Receptor Type-3 Synonyms
Neurotrophic Tyrosine Kinase Receptor Type 3, GP145-TRKC, NT3 Growth Factor Receptor, NTRK3, TRKC, TRKC Tyrosine Kinase
Terms in Neurotrophic Tyrosine Kinase Receptor Type-3 category
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