Nitric Oxide Synthase-2B
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Nitric Oxide Synthase-2B Definition
Encoded by human NOS2B Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2B binds FAD and FMN cofactors, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2B may bind SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. (NCI)
Nitric Oxide Synthase-2B Synonyms
Nitric Oxide Synthase 2B, NOS Type IIB, NOS2B, NOSIIB, Nitric Oxide Synthase IIB
Terms in Nitric Oxide Synthase-2B category
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