Nitric Oxide Synthase-2C
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Nitric Oxide Synthase-2C Definition
Encoded by human NOS2C Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2C binds FAD and FMN cofactors, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2C may bind SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. (NCI)
Nitric Oxide Synthase-2C Synonyms
Nitric Oxide Synthase 2C, NOS Type IIC, NOS2C, NOSIIC, Nitric Oxide Synthase IIC
Terms in Nitric Oxide Synthase-2C category
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