Cancer Terms

Nitric Oxide Synthase-2C

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Oxidoreductase -> Nitric Oxide Synthetase -> Nitric Oxide Synthase-2C

Nitric Oxide Synthase-2C Definition

Encoded by human NOS2C Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2C binds FAD and FMN cofactors, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2C may bind SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. (NCI)

Nitric Oxide Synthase-2C Synonyms

Nitric Oxide Synthase 2C, NOS Type IIC, NOS2C, NOSIIC, Nitric Oxide Synthase IIC

Terms in Nitric Oxide Synthase-2C category



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