Nitric Oxide Synthetase
Cancer Terms ->
Gene Product ->
Protein ->
Protein Organized by Function ->
Enzyme ->
Oxidoreductase -> Nitric Oxide Synthetase
Nitric Oxide Synthetase Definition
Expressed in various cell types, Nitric Oxide Synthases (NOS Family) are constitutive or inducible calcium/calmodulin stimulated homodimers stabilized by BH4 that bind FAD and FMN cofactors, generally contain a flavodoxin-like domain, and synthesize reactive free radical nitric oxide messenger from L-arginine. NO can act as a neurotransmitter and has antimicrobial and antitumoral activities in macrophages. IL12 requires NOS to stimulate tyrosine-phosphorylation of STAT4 by TYK2 in NK cytotoxicity. Vascular NO (endothelia) inhibits muscle contraction through a cGMP pathway, inhibits platelet aggregation, and mediates VEGF-induced angiogenesis. Endothelial AKT phosphorylates and enhances NOS activity. Potentially influencing energy balance, NO can trigger cGMP-dependent mitochondrial biogenesis mediated by induction of the master regulator PPARGC1. (NCI)
Nitric Oxide Synthetase Synonyms
Nitric Oxide Synthetase, EC 1.14.13.39, NADPH-Diaphorase, NO Synthase, Nitric Oxide Synthase, Nitric-Oxide Synthase
Terms in Nitric Oxide Synthetase category
Nitric Oxide Synthase-2ANitric Oxide Synthase-2BNitric Oxide Synthase-2CNitric Oxide Synthase-3Nitric Oxide Synthetase-1
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.