Nitrogen Mustard
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Nitrogen Mustard Definition
The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intermediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties.
Nitrogen Mustard Synonyms
Mechlorethamine Hydrochloride, Bis(2-chloroethyl)methylamine Hydrochloride, Caryolysine, Chlorethamine HCl, Chlorethazine Hydrochloride, Chlormethine Hydrochloride, Chlormethine hydrochloride, Chloromethine HCl, Chloromethine Hydrochloride, Cloramin, Erasol, HN 2 Hydrochloride, MECHLORETHAMINE HYDROCHLORIDE, Mechlorethamine hydrochloride, Methylbis(beta-chloroethyl)amine Hydrochloride, Methylchlorethamine Hydrochloride, Mustargen, Mustargen HCl, Mustargen Hydrochloride, Mustargen hydrochloride, Mustine Hydrochloride, Mustine hydrochloride, N-Lost, Onco-Cloramin, WR-147650, chlorethamine hydrochloride, ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl Hydrochloride, mechlorethamine HCl
Terms in Nitrogen Mustard category
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