Cancer Terms

Non-Receptor Type 12 Protein Tyrosine Phosphatase

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Hydrolase -> Phosphatase -> Phosphoprotein Phosphatase -> Protein Tyrosine Phosphatase -> Non-Receptor Type 12 Protein Tyrosine Phosphatase

Non-Receptor Type 12 Protein Tyrosine Phosphatase Definition

Encoded by human PTPN12 Gene (Non-Receptor PTP Family), 780-aa 88-kDa cytoplasmic Non-Receptor Type 12 Protein Tyrosine Phosphatase contains a C-terminal PEST motif protein-protein interaction domain. PTPN12 binds to and dephosphorylate the c-ABL product. It also interacts with, and dephosphorylates, cytoskeletal and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and Paxillin, suggesting a role in controlling cell shape and mobility. PTPs typically regulate cell growth, differentiation, and mitotic cycle. Defects in PTPN12 are found in some colon cancers. (NCI)

Non-Receptor Type 12 Protein Tyrosine Phosphatase Synonyms

Protein Tyrosine Phosphatase, Non-Receptor Type 12, PTPN12, Protein Tyrosine Phosphatase G1

Terms in Non-Receptor Type 12 Protein Tyrosine Phosphatase category



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