Notch4 Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Notch4 Protein

Notch4 Protein Definition

NOTCH4 Protein is a Drosophila Notch receptor homologue with 29 extracellular EGF-like repeats, three Notch/lin-12 repeats, a transmembrane region, six intracellular cdc10/ankyrin repeats, a polyglutamine domain, and a C-terminal PEST region. A component of an evolutionarily conserved intercellular signaling mechanism, NOTCH4 is expressed in a variety of tissues and appears to regulate cell fate decisions during embryonic vascular morphogenesis and remodeling. NOTCH4 and NOTCH1 appear to have partially overlapping roles during embryogenesis in mice. MMTV INT3 interruption of NOTCH4 produces a gain-of-function truncated product, containing only the transmembrane and intracellular domains, that has profound consequences for mammary gland development and tumorigenesis. (from OMIM 164951 and NCI)

Notch4 Protein Synonyms

Notch4 Protein, Human Homolog 4 of Drosophila Notch4 Protein, NOTCH4, Notch4 / Int3 Gene Product

Notch4 Protein

Notch4 Protein Definition

Notch4 Protein Synonyms

Terms in Notch4 Protein category