Nuclear Receptor

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Nuclear Receptor

Nuclear Receptor Definition

Proteins that regulate transcription via interaction with chromatin and basal transcription machinery at the promoter regions of genes. Nuclear receptors are ligand-dependent transcription factors including steroids, retinoids, vitamin D, unliganded thyroid hormone, and orphan receptors (unknown ligands). Coregulators (coactivators or corepressors) are important in mediating these interactions and thereby modulate positive or negative receptor activity.

Nuclear Receptor Synonyms

Nuclear Receptor, Receptor, Nuclear

Terms in Nuclear Receptor category

Peroxisome Proliferative Activated Receptor Gamma