Nuclear Receptor Co-Repressor-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Repressor Corepressor -> Nuclear Receptor Co-Repressor-1

Nuclear Receptor Co-Repressor-1 Definition

Nuclear Receptor Co-Repressor 1, encoded by the NCOR1, mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. This protein is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined. (from LocusLink)

Nuclear Receptor Co-Repressor-1 Synonyms

Nuclear Receptor Co-Repressor 1, KIAA1047, N-CoR, N-CoR1, NCOR1, Nuclear Receptor Corepressor, TRAC1, Thyroid Hormone- and Retinoic Acid Receptor-Associated Corepressor 1, hCIT529I10, hN-CoR

Nuclear Receptor Co-Repressor-1

Nuclear Receptor Co-Repressor-1 Definition

Nuclear Receptor Co-Repressor-1 Synonyms

Terms in Nuclear Receptor Co-Repressor-1 category