Nuclear Receptor Co-Repressor-2

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Repressor Corepressor -> Nuclear Receptor Co-Repressor-2

Nuclear Receptor Co-Repressor-2 Definition

SMRT is a receptor-interacting factor for retinoid and thyroid-hormone receptors. The repressor function of thyroid hormone and retinoic acid receptors involves direct interaction with SMRT, possibly by stabilizing/promoting interaction with transcription factor TFIIB. Ligand causes SMRT dissociation from the receptor, triggering activation. Binding of ligand to nuclear hormone receptors induces a conformation that attracts co-activator proteins containing a NR box. NCOR1 has a similar NR box, CoRNR box, that is required for nuclear hormone receptor interaction. Sequences flanking the corner box determine nuclear hormone receptor specificity. Hormone action and differential recognition of unliganded and liganded nuclear hormone receptors by co-activators and co-repressors appears to be due to subtle differences between CoRNR and NR boxes. (from OMIM 600848 and NCI)

Nuclear Receptor Co-Repressor-2 Synonyms

Nuclear Receptor Co-Repressor 2, NCOR2, SMRT, Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptors, T3 Receptor-associating Factor

Nuclear Receptor Co-Repressor-2

Nuclear Receptor Co-Repressor-2 Definition

Nuclear Receptor Co-Repressor-2 Synonyms

Terms in Nuclear Receptor Co-Repressor-2 category