Nuclear Receptor Coactivator Gene

Cancer Terms -> Gene -> Regulatory Gene -> Transcription Coregulator Gene -> Transcription Coactivator Gene -> Nuclear Receptor Coactivator Gene

Nuclear Receptor Coactivator Gene Definition

Nuclear receptor coactivator genes encode a class of proteins that are recruited and serve as bridging molecules between the transcription initiation complex and nuclear receptors (NRs). Most of these coactivators interact with the AF-2 domain of NRs through one or several LXXLL motifs called NR box. Members of NRs includes the 5 steroid receptors and class II nuclear receptors. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation. (NCI)

Nuclear Receptor Coactivator Gene Synonyms

Terms in Nuclear Receptor Coactivator Gene category

NCOA1 Gene
NCOA2 Gene
NCOA3 Gene
NCOA4 Gene
NCOA5 Gene
NCOA6 Gene
NR4A1 Gene