Nuclear Receptor Coactivator-6
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Nuclear Receptor Coactivator-6 Definition
Encoded by human NCOA6 Gene, ubiquitous 2063-aa 250-kDa mono-/homodimeric Nuclear Receptor Coactivator 6 is a general and nuclear receptor transcriptional coactivator of the ASCOM complex containing two LXXLL motifs (the first mediates ligand-dependent interaction with receptor AF2 domains). NCOA6 directly binds prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors, to strongly enhance transcription in a ligand-/AF2-dependent manner. NCOA6 also appears to interact with RNPC2, NCOA1, CRSP3, RBM14, histone acetyltransferases EP300 and CREBBP, methyltransferases NCOA6IP and HRMT1L1/PRMT2, and with basal transcription factors GTF2A and TBP. Phosphorylated by PRKDC, NCOA6 may coactivate expression via chromatin remodeling and interaction with histone acetyltransferases. It may be involved in coactivation of the NF-kappa-B pathway. (NCI)
Nuclear Receptor Coactivator-6 Synonyms
Nuclear Receptor Coactivator 6, AIB3, ASC2, Activating Signal Cointegrator-2, Amplified in Breast Cancer-3 Protein, Cancer-Amplified Transcriptional Coactivator ASC-2, NCOA6, NRC, Nuclear Receptor Coactivator RAP250, Nuclear Receptor-Activating Protein 250 kDa, PPAR-Interacting Protein, PRIP, Peroxisome Proliferator-Activated Receptor Interacting Protein, RAP250, TRBP, Thyroid Hormone Receptor Binding Protein
Terms in Nuclear Receptor Coactivator-6 category
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