Cancer Terms

Nucleotide Excision Repair

Cancer Terms -> Biological Process -> Subcellular Process -> Biochemical Process -> DNA Maintenance Process -> DNA Maintenance -> DNA Repair -> Excision Repair -> Nucleotide Excision Repair

Nucleotide Excision Repair Definition

Nucleotide Excision Repair (NER) mends DNA regions that contain chemical adducts, such as UV-induced thymine dimers or carcinogenic adducts, which distort the DNA helix and interfere with replication and transcription. NER is targeted to actively transcribed regions of the genome. During NER in eukaryotes, shape irregularities are detected by protein complexes that slide along the DNA molecule and induce cuts on each side of a lesion several nucleotides away. Removal of the damaged 25-30 nucleotide fragment is followed by repair synthesis and ligation.

Nucleotide Excision Repair Synonyms

Nucleotide Excision Repair, NER, Nucleotide-Excision Repair, Transcription-Coupled Nucleotide Excision Repair, Transcription-Coupled Repair

Terms in Nucleotide Excision Repair category



Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods

No reproduction or republication permitted.