Nucleotide Excision Repair
Cancer Terms ->
Biological Process ->
Subcellular Process ->
Biochemical Process ->
DNA Maintenance Process ->
DNA Maintenance ->
DNA Repair ->
Excision Repair -> Nucleotide Excision Repair
Nucleotide Excision Repair Definition
Nucleotide Excision Repair (NER) mends DNA regions that contain chemical adducts, such as UV-induced thymine dimers or carcinogenic adducts, which distort the DNA helix and interfere with replication and transcription. NER is targeted to actively transcribed regions of the genome. During NER in eukaryotes, shape irregularities are detected by protein complexes that slide along the DNA molecule and induce cuts on each side of a lesion several nucleotides away. Removal of the damaged 25-30 nucleotide fragment is followed by repair synthesis and ligation.
Nucleotide Excision Repair Synonyms
Nucleotide Excision Repair, NER, Nucleotide-Excision Repair, Transcription-Coupled Nucleotide Excision Repair, Transcription-Coupled Repair
Terms in Nucleotide Excision Repair category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.