Cancer Terms

OTF-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Factor -> Homeobox Protein -> OTF-1

OTF-1 Definition

Encoded by human POU2F1 Gene (POU2 Family), ubiquitous transcription factor OTF-1 contains one homeobox domain, binds to the octamer ATTTGCAT motif, and activates genes for some snRNA, histone H2B, and immunoglobulins. POU domain proteins contain a bipartite DNA-binding domain divided by a flexible linker that enables diverse monomeric configurations on DNA; additional versatility is conferred by dimerization. OTF-1 POU dimers on palindromic OCT factor recognition elements, or PORE, (ATTTGAAATGCAAAT) can recruit transcriptional coactivator OBF1. OTF-1 interacts with transcription activators NR3C1, AR, and PGR. (from LocusLink, Swiss-Prot, and NCI)

OTF-1 Synonyms

POU Domain, Class 2, Transcription Factor 1, Lymphoid-Specific OTF 1, NF-A1, NF-III, Nuclear Factor III, OCT-1, OTF-1, Octamer Transcription Factor-1, Octamer-Binding Transcription Factor 1, POU2F1

Terms in OTF-1 category



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