Olsalazine
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Olsalazine Definition
A prodrug of mesalamine (5-Aminosalicylic acid; 5-ASA) with anti-inflammatory activity. Unabsorbed olsalazine passes through gastrointestinal tract and is cleaved by azoreductases, produced by microflora in colon, into 2 active molecules of 5-ASA. 5-ASA exerts its anti-inflammatory action locally by inhibiting cyclooxygenase and lipoxygenase activities, thereby reducing the production of prostaglandins and leukotrienes. In addition, mesalamine may act as a scavenger of reactive oxygen free radicals.
Olsalazine Synonyms
Olsalazine, 3,3'-Azobis[6-hydroxybenzoic Acid], 3,3'-Dicarboxy-4,4'-dihydroxyazobenzene, Azodisalicylate, C.I. Mordant Yellow 5, Dipentum, OLSALAZINE
Terms in Olsalazine category
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