Oncogene ErbB2
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Oncogene ErbB2 Definition
Human Oncogene ErbB2 is a mutated variant of ERBB2 Gene, which encodes ERRB2 Receptor Protein Tyrosine Kinase, a 185-kDa type I membrane glycoprotein similar to EGFR that controls cell growth. Ligand binding increases ERBB2 tyrosine phosphorylation. A heterodimer with ERBB3 and ERBB4, p185ERBB2 is an essential component of the heregulin/neuregulin receptor. ERBB2 forms an IL6-dependent complex with IL6R gp130, resulting in ERBB2 tyrosine phosphorylation and MAPK activation. Oncogene ERBB2 disrupts normal cell function.
Oncogene ErbB2 Synonyms
Oncogene ErbB2, HER -2, HER-2/NEU, Oncogene, C-Erb -2, Oncogene, C-ErbB-2, Oncogene, ERBB2, Oncogene, NEU
Terms in Oncogene ErbB2 category
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