Oncogene HST
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Oncogene HST Definition
Human Oncogene HST is a mutated variant of FGF4 Gene (FGF Family) about 35 kb downstream of INT2 (same orientation), which encodes Fibroblast Growth Factor 4, a heparin-binding growth factor with homology to basic and acidic FGF. Gremlin relays an SHH signal from the polarizing region to the apical ectodermal ridge. Formin-dependent activation of BMP-antagonist Gremlin induces FGF4 and the SHH/FGF4 feedback loop. Oncogene HST disrupts normal cell function.
Oncogene HST Synonyms
Oncogene HST, FGF4, FGF4 Oncogene, Fibroblast Growth Factor 4 Oncogene, HSTF1, Human Stomach Cancer Derived Oncogene, K-FGF, Kaposi Sarcoma Oncogene
Terms in Oncogene HST category
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