Oncogene LCK

Cancer Terms -> Gene -> Cancer Gene -> Oncogene -> Protein-Kinase Oncogene -> Tyrosine-Kinase Oncogene -> Oncogene LCK

Oncogene LCK Definition

Human Oncogene LCK is a mutated variant of LCK Gene, which encodes p56LCK, a lymphocyte-specific tyrosine protein kinase with an SH2 and SH3 domain. LCK may participate in T-cell activation; p56LCK regulates allelic exclusion at the TCR beta locus. It binds to CD4, CD8 and IL-2R beta chain cytoplasmic domains. p56LCK is quickly activated by mIg cross-linking on B-cells or by TCR cross-linking. Pre-TCR co-localizes with p56LCK kinase in membrane rafts resulting in phosphorylation of CD3-epsilon and ZAP70. p56LCK, in the TCR complex, activates DNA binding of STAT5A and STAT5B. Oncogene LCK disrupts normal cell function.

Oncogene LCK Synonyms

Oncogene LCK

Terms in Oncogene LCK category

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