Oncogene MYB
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Oncogene MYB Definition
Human Oncogene MYB is a mutated variant of MYB Gene, which encodes 6 alternative isoforms of 640 aa 72-kDa nuclear c-MYB protein, a DNA-binding transcriptional activator critical for hematopoietic progenitor cell proliferation and differentiation. MYB contains 3 N-terminal MYB-like DNA-binding domains that specifically recognize YAAC[GT]G, a central transcriptional activation domain and a C-terminal transcriptional repression domain. MYB may interact with HIPK2 and NLK; phosphorylation by NLK on multiple sites may induce proteasomal degradation. Ubiquitination may be mediated by SIAH1. Oncogene MYB disrupts normal cell function.
Oncogene MYB Synonyms
Oncogene MYB, Avian Myeloblastosis Viral (v-MYB) Oncogene Homolog, MYB, Oncogene AMV, v-MYB Avian Myeloblastosis Viral Oncogene Homolog
Terms in Oncogene MYB category
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