Oral Pan-VEGFR TIE2 Tyrosine Kinase Inhibitor CEP-11981
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Oral Pan-VEGFR TIE2 Tyrosine Kinase Inhibitor CEP-11981 Definition
An orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR) and Tie2 receptor tyrosine kinases with potential antiangiogenic and antineoplastic activities. Pan-VEGFR/Tie2 tyrosine kinase inhibitor CEP-11981 selectively binds to VEGFR and Tie2 receptor tyrosine kinases, which may result in the inhibition of endothelial cell migration, proliferation and survival and the inhibition of tumor cell proliferation and tumor cell death. VEGFR and Tie2 are frequently overexpressed by a variety of tumor cell types and play crucial roles in the regulation of angiogenesis and the maintenance of tumor blood vessels. Tie2 (tyrosine kinase with immunoglobulin-like and EGF-like domains) is activated by angiopoietin-1 (Ang-1).
Oral Pan-VEGFR TIE2 Tyrosine Kinase Inhibitor CEP-11981 Synonyms
Oral Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981, CEP-11981
Terms in Oral Pan-VEGFR TIE2 Tyrosine Kinase Inhibitor CEP-11981 category
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