Oral Smoothened Antagonist LDE225
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Signal Transduction Inhibitor -> Oral Smoothened Antagonist LDE225
Oral Smoothened Antagonist LDE225 Definition
An orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LDE225 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway and, so, the inhibition of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Inappropriate activation of Hh pathway signaling and uncontrolled cellular proliferation, as is observed in a variety of cancers, may be associated with mutations in the Hh-ligand cell surface receptor Smo.
Oral Smoothened Antagonist LDE225 Synonyms
Oral Smoothened Antagonist LDE225, LDE225
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