Origin Recognition Complex Subunit-3

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> DNA Binding Protein -> Sequence-Specific DNA Binding Protein -> Origin Recognition Complex Subunit-3

Origin Recognition Complex Subunit-3 Definition

Human ORC3L Gene (ORC3 Family) encodes 711-aa 82-kDa nuclear Origin Recognition Complex Subunit 3, one of 6 conserved subunits of the ORC complex that binds to the consensus ACS of Origins in an ATP-dependent manner, serves as a platform for assembly of additional initiation factors such as CDC6 and MCM proteins, initiates DNA replication, and is essential for viability. Bound to origins throughout the cell cycle, ORC and associated factors modulate local chromatin structure to facilitate replication initiation. Important for G1/S transition and containing HLH motifs, ORC3L forms a core ORC complex with ORC2, -3, -4, and -5. The ORC3 N-terminus interacts with the ORC2 C-terminus. The ORC3 C-terminus region brings ORC4 and ORC5 into the core complex. ORC3L has a role in transcriptional silencing and perhaps in neuronal proliferation and olfactory memory. (NCI)

Origin Recognition Complex Subunit-3 Synonyms

Origin Recognition Complex Subunit 3, LAT, LATHEO, Latheo Homolog, ORC3, ORC3L, Origin Recognition Complex Subunit 3-Like, Origin Recognition Complex Subunit Latheo

Terms in Origin Recognition Complex Subunit-3 category

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