Origin Recognition Complex Subunit-4
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Origin Recognition Complex Subunit-4 Definition
Human ORC4L Gene (ORC4 Family) encodes 436-aa 50-kDa nuclear Origin Recognition Complex Subunit 4, one of 6 conserved subunits of the ORC complex that binds to the consensus ACS of Origins in an ATP-dependent manner, serves as a platform for assembly of additional initiation factors such as CDC6 and MCM proteins, initiates DNA replication, and is essential for viability. Bound to origins throughout the cell cycle, ORC and associated factors modulate local chromatin structure to facilitate replication initiation. ORC4L has a putative nucleotide triphosphate binding motif, associates with multiple cellular proteins, forms a core ORC complex with ORC2L, -3L, and -5L, and has a role in transcriptional silencing. (NCI)
Origin Recognition Complex Subunit-4 Synonyms
Origin Recognition Complex Subunit 4, ORC4, ORC4L, ORC4P, Origin Recognition Complex Subunit 4-Like
Terms in Origin Recognition Complex Subunit-4 category
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