Ornithine Decarboxylase-1
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Ornithine Decarboxylase-1 Definition
Expressed most at G1/S and G2/M by human ODC1 Gene (Orn/Lys/Arg Decarboxylase Class-II Family), 461-aa 51-kDa Ornithine Decarboxylase 1 is a homodimeric rate-limiting enzyme with high turnover rate and pyridoxal phosphate cofactor that catalyzes conversion of ornithine to putrescine in the first step of the polyamine biosynthesis pathway. ODC promoter activity is influenced by cooperative E-box interactions, a cap-independent IRES in the mRNA functions at G2/M to ensure adequate polyamine levels, and enzyme activity fluctuates in response to growth-promoting stimuli. (NCI)
Ornithine Decarboxylase-1 Synonyms
Ornithine Decarboxylase 1
Terms in Ornithine Decarboxylase-1 category
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