Orphan Nuclear Receptor-SHP
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Orphan Nuclear Receptor-SHP Definition
Expressed in small intestine, spleen, liver, heart, adrenal gland, and pancreas, human NR0B2 Gene (NR0 Family) encodes 257-aa 28-kDa Orphan Nuclear Receptor SHP, containing a putative ligand-binding domain and a dimerization domain, but lacking a conventional DNA-binding domain. SHP heterodimerizes with nuclear hormone receptors ESR, RAR, RXR, TR, and NR1I3, specifically inhibiting their ligand-dependent transcriptional activation pathways. SHP may repress nuclear receptor-mediated transactivation via two steps: competition with coactivators and direct transcriptional repression. (NCI)
Orphan Nuclear Receptor-SHP Synonyms
Orphan Nuclear Receptor SHP, NR0B2, Nuclear Receptor Subfamily 0 Group B Member 2, SHP, SHP1, Short Heterodimer Partner
Terms in Orphan Nuclear Receptor-SHP category
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