Ossirene

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Biological Response Modifier -> Immunostimulant -> Ossirene

Ossirene Definition

A synthetic non-toxic tellurium derivative, structurally similar to cisplatin, with immunostimulatory and anti-hair loss properties. Ammonium trichlorotellurate induces production of colony stimulating factor (CSF), interleukin-2 (IL-2), and IL-2 receptors by increasing the calcium ion influx through the cell membrane and subsequently exerts its immunostimulatory effects through the CSF-mediated increase in macrophage/granulocytes. This agent is also a potent inducer of interferon and a spectrum of cytokines such as IL-1, IL-6, and tumor necrosis factor (TNF). In animal studies, ammonium trichlorotellurate exerts its anti-hair loss effect by inducing anagen and obstructing spontaneous catagen via promoting follicular keratinocyte proliferation and interfering with terminal differentiation, respectively.

Ossirene Synonyms

Ammonium Trichlorotellurate, AS-101, IVX-Q-101, Ossirene, Tellurate(1-), trichloro[1,2-ethanediolato(2-)-.kappa.O,.kappa.O']-,ammonium, (SP-5-22)-

Terms in Ossirene category

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