Cancer Terms

Osteoprotegerin

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Cytokine Receptor -> TNF Receptor Family Protein -> Osteoprotegerin

Osteoprotegerin Definition

Widely expressed by estrogen- and glucocorticoid-regulated human TNFRSF11B Gene (TNFR Family), 401-aa 46-kDa (precursor) N-glycosylated homodimeric secreted Tumor Necrosis Factor Receptor Superfamily Member 11B contains a blocked N-terminus, 4 TNFR-Cys repeats, 2 death domains, and sialic acid residues. TNFRSF11B acts as a regulator of bone homeostasis and osteoclast development. A decoy receptor for RANKL (TNFSF11/OPGL), TNFRSF11B inhibits activation of osteoclasts (osteoclastogenesis) and promotes osteoclast apoptosis. TNFRSF11B may also act as decoy receptor for TRAIL, protecting against apoptosis and inhibition of osteoclastogenesis. (NCI)

Osteoprotegerin Synonyms

Tumor Necrosis Factor Receptor Superfamily Member 11B, Osteoclastogenesis Inhibitory Factor, Osteoprotegerin, TNFRSF11B

Terms in Osteoprotegerin category



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