PI3K Inhibitor GSK1059615
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PI3K Inhibitor GSK1059615 Definition
A phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor GSK1059615 inhibits PI3K in the PI3K/AKT kinase signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane and an increase in mitochondrial membrane permeability, followed by apoptosis. Bax is a member of the proapoptotic Bcl-2 family of proteins. PIK3, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.
PI3K Inhibitor GSK1059615 Synonyms
PI3K Inhibitor GSK1059615, GSK1059615
Terms in PI3K Inhibitor GSK1059615 category
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