PML wt Allele
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PML wt Allele Definition
Human PML wild-type allele is located in the vicinity of 15q22 and is approximately 53 kb in length. This allele, which encodes probable transcription factor PML protein, plays a role in transcription, repair, recombination of DNA and apoptosis through the formation of specialized bodies (PML bodies) of nuclear proteins. Acute promyelocytic leukemia is associated with the translocation t(15;17)(q22;q21) of the gene and the RARA gene.
PML wt Allele Synonyms
PML wt Allele, MYL, PML, Promyelocytic Leukemia wt Allele, TRIM19
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