PPE-Expressing Nonreplicating HSV-1-Based Vector NP2
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Biological Agent ->
Gene Transfer or Gene Delivery Agent -> PPE-Expressing Nonreplicating HSV-1-Based Vector NP2
PPE-Expressing Nonreplicating HSV-1-Based Vector NP2 Definition
A replication-defective (ICP4-deleted) herpes simplex virus type 1 (HSV-1) viral vector expressing the human preproenkephalin A (PPE) gene with potential antinociceptive activity. Upon intradermal administration, PPE-expressing replication-defective HSV-1 vector NP2 is transported by retrograde axonal transport to the dorsal root ganglion (DRG) and becomes dormant. In the DRG, the vector transduces sensory neurons with high efficiency, delivering the engineered PPE gene; transduced neurons then express the protein proenkephalin A, the precursor for Met- and Leu-enkephalin. After proteolytic cleavage from proenkephalin A in the DRG neuronal cytosol, transgene-mediated Met- and Leu-enkephalin bind to mu and gamma- opioid receptors, which may result in the inhibition of nociceptive neurotransmission.
PPE-Expressing Nonreplicating HSV-1-Based Vector NP2 Synonyms
PPE-Expressing Replication-Defective HSV-1 Vector NP2, NP2, Preproenkephalin-Expressing Replication-Defective Herpes Simplex Virus-1 Vector NP2
Terms in PPE-Expressing Nonreplicating HSV-1-Based Vector NP2 category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.