PS2 Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> PS2 Protein

PS2 Protein Definition

Expressed in breast, pancreas, stomach, and gastrointestinal epithelium, estrogen-responsive human TFF1 Gene (Trefoil Family) encodes cysteine-rich secretory 84-aa 9-kD (precursor) PS2 Protein, a likely tumor suppressor containing one P-type trefoil domain and a 40-aa domain with three conserved disulfides. TFF1 appears to play a complex repressor role in cell progression towards S phase (G1/S transition) and in apoptosis; TFF1 may promote cell differentiation and tissue repair. TFF1 may protect the gastrointestinal mucosa from insults, stabilize the mucus layer, and affect epithelial healing; strong expression is found in GI tract regenerative tissues. The exact function of TFF1/PS2 has not yet been determined. (NCI)

PS2 Protein Synonyms

PS2 Protein, Breast Cancer Estrogen-Inducible Protein, Gastrointestinal Trefoil Protein PS2, PS2, TFF1, Trefoil Factor 1, Trefoil Protein 1

PS2 Protein

PS2 Protein Definition

PS2 Protein Synonyms

Terms in PS2 Protein category