PUR Alpha Protein
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PUR Alpha Protein Definition
PURA is a potent transactivator able to bind purine-rich DNA sequences (GAGA boxes), often found upstream of gene transcription start sites. PURA is implicated in transcriptional control of many cellular genes, including MBP, FE65, and neuronal ACHR, as well as viral promoters for JCV and HIV-1. PURA is also involved in cell growth control and interacts with hypophosphorylated RB1. It interacts with large T-antigen and cellular protein YB-1 to activate JC viral DNA transcription. PURA is also a single-stranded DNA-binding protein with specific affinity for a (GGN)n element present in several eukaryotic DNA replication initiation zones.
PUR Alpha Protein Synonyms
PUR Alpha, PURA, Purine-Rich Element Binding Protein A, Transcription Factor PUR1
Terms in PUR Alpha Protein category
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