PXD101
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Histone Deacetylase Inhibitor -> PXD101
PXD101 Definition
A novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.
PXD101 Synonyms
Belinostat, PXD 101, PXD101
Terms in PXD101 category
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