Paired Box-5 Protein
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Paired Box-5 Protein Definition
Paired Box 5, encoded by the PAX5 gene, is a member of the paired box (PAX) family of transcription factors. Paired Box 5 is expressed at early stages of B-cell differentiation. Its expression is also detected in developing CNS and testis. Paired Box 5 may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. This gene is located in chromosome 9p13 region, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoters. Deregulation of PAX5 gene transcription may contribute to the pathogenesis of these lymphomas. (from LocusLink)
Paired Box-5 Protein Synonyms
Paired Box Protein Pax-5, B-Cell Lineage Specific Activator Protein, B-Cell Specific Transcription Factor, BSAP, PAX5, Paired Box 5, Paired Box Homeotic Gene 5
Terms in Paired Box-5 Protein category
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