Cancer Terms

Pan-AKT Inhibitor GSK-690693

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Enzyme Inhibitor -> Protein Kinase Inhibitor -> Serine Threonine Kinase Inhibitor -> Pan-AKT Inhibitor GSK-690693

Pan-AKT Inhibitor GSK-690693 Definition

An aminofurazan-derived inhibitor of Akt kinases with potential antineoplastic activity. Pan-AKT kinase inhibitor GSK-690693 binds to and inhibits Akt kinases 1, 2, and 3, which may result in the inhibition of protein phosphorylation events downstream from Akt kinases in the PI3K/Akt signaling pathway, and, subsequently, the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. In addition, this agent may inhibit other protein kinases including protein kinase C (PKC) and protein kinase A (PKA). As serine/threonine protein kinases which are involved in a number of biological processes, AKT kinases promote cell survival by inhibiting apoptosis and are required for glucose transport.

Pan-AKT Inhibitor GSK-690693 Synonyms

Pan-AKT Kinase Inhibitor GSK690693, GSK690693

Terms in Pan-AKT Inhibitor GSK-690693 category



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