Penciclovir Sodium
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Penciclovir Sodium Definition
The sodium salt form of penciclovir, a synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited.
Penciclovir Sodium Synonyms
Penciclovir Sodium, 1,9-Dihydro-2-amino-9-(4-hydroxy-3-(hydroxymethyl)butyl)-6H-purin-6-one Monosodium Salt, 9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine, Monosodium Salt, Denavir, PENCICLOVIR SODIUM
Terms in Penciclovir Sodium category
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