Cancer Terms

Penclomedine

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Alkylating Agent -> Antineoplastic Alkylating Agent -> Picoline Compound -> Penclomedine

Penclomedine Definition

A synthetic derivative of pyrimidine with antineoplastic activity. Penclomedine alkylates and crosslinks DNA, resulting in DNA strand breaks and inhibition of DNA and RNA synthesis. This agent is more active against tumor cells that are defective in p53 function. (NCI04)

Penclomedine Synonyms

Penclomedine, 3,5-dichloro-2,4-dimethoxy-6-(trichloromethyl) pyridine, CRC 88-04, PEN, Pyridine, 3,5-dichloro-2,4-dimethoxy-6-(trichloromethyl)-, penclomedine

Terms in Penclomedine category



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