Cancer Terms

Peroxisome Proliferative Activated Receptor Gamma

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Nuclear Receptor -> Peroxisome Proliferative Activated Receptor Gamma

Peroxisome Proliferative Activated Receptor Gamma Definition

Expressed as multiple variants in adipose tissue (highest), skeletal muscle, spleen, heart, liver placenta, lung, and ovary by human PPARG Gene (NR1/PPAR Family), nuclear Peroxisome Proliferative Activated Receptor Gamma heterodimerizes with RXRs and NCOA6 coactivator to regulate target gene transcription. A receptor that binds peroxisome proliferators, such as hypolipidemic drugs and fatty acids, PPARG is a key regulator of adipocyte differentiation and glucose homeostasis. Once activated by ligand, PPARG binds to an acyl-CoA oxidase gene promoter element, activates transcription, and controls the peroxisomal fatty acid beta-oxidation pathway. Defects in PPARG can lead to type 2 insulin-resistant diabetes and hypertension. (NCI)

Peroxisome Proliferative Activated Receptor Gamma Synonyms

Peroxisome Proliferative Activated Receptor Gamma, PPAR Gamma, PPARG, PPARG1, PPARG2

Terms in Peroxisome Proliferative Activated Receptor Gamma category



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