Phosphatase-2A Inhibitor-I2PP2A
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Phosphatase-2A Inhibitor-I2PP2A Definition
Expressed by human SET Gene (NAP Family) in all tissues and responsive to serum factors, contact inhibition, or differentiation, 277-aa 32-kDa nuclear Phosphatase 2A Inhibitor I2PP2A is a specific inhibitor of PP2A that may be involved in intracellular signaling after ligand activation of HLA class II molecules. Serine phosphorylated SET has a long acidic C-terminus and SET domain. Located in an ER-associated complex containing pp32, HMG2, and APE1, SET is a specific inhibitor of GZMA-activated DNase/nucleoside diphosphate kinase (GAAD/NM23H1), which mediates GZMA-induced caspase-independent apoptosis characterized by single-stranded DNA nicks. GZMA cleavage of SET releases NM23H1 from bound inhibition to SET and results in SET degradation, NM23H1 translocation to the nucleus, and NM23H1 nicking of DNA. (NCI)
Phosphatase-2A Inhibitor-I2PP2A Synonyms
Phosphatase 2A Inhibitor I2PP2A, 2PP2A, HLA-DR Associated Protein II, I2PP2A, IGAAD, Inhibitor of GZMA-Activated DNase, PHAPII, SET, SET Protein, SET Translocation Inhibitor-2 of Protein Phosphatase-2A, TAF-IBeta, Template Activating Factor I Beta
Terms in Phosphatase-2A Inhibitor-I2PP2A category
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