Phosphatidic Acid Phosphatase Type-2A
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Phosphatidic Acid Phosphatase Type-2A Definition
Expressed ubiquitously by human PPAP2A Gene (PAP Family), 284-aa 32-kDa Phosphatidic Acid Phosphatase Type 2A is a type 2 integral plasma membrane glycoprotein enzyme with extracellular activity predicted to contain 6 transmembrane regions and a conserved N-glycosylation site. PPAP2A exhibits 47% sequence identity with PPAP2B and 54% identity with PPAP2C; the C-terminal 40-aa of PPAP2A, PPAP2B, and PPAP2C show greatest divergence. PPAP2A has an active role in metabolic pathways controlling synthesis of glycerophospholipids and triacylglycerols, in hydrolysis and uptake of lipids from the extracellular space, in dephosphorylation of phosphatidic acid to diacylglycerol, and in receptor-activated signal transduction mediated by phospholipase D. (NCI)
Phosphatidic Acid Phosphatase Type-2A Synonyms
Phosphatidic Acid Phosphatase Type 2A, PAP2, PAP2A, PPAP2A, Phosphatidic Acid Phosphatase 2A, Phosphatidic Acid Phosphohydrolase Type 2A, Type 2 Phosphatidic Acid Phosphohydrolase, Type-2 Phosphatidic Acid Phosphatase Alpha
Terms in Phosphatidic Acid Phosphatase Type-2A category
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