Phosphatidylinositol-4-Phosphate-5-Kinase Type-II Beta

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Phosphatidylinositol-4-Phosphate-5-Kinase Type-II Beta Definition

Abundantly expressed (6.3-kb mRNA) in many tissues, human PIP5K2B Gene (PtdIns(4)P-5-Kinase Family) encodes 416-aa plasma membrane targeted Phosphatidylinositol-4-Phosphate 5-Kinase Type II Beta, a homodimer 78% identical in sequence to PIP5K2A that catalyzes phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate, precursor to second messengers of phosphoinositide signal transduction pathways involved in regulation of secretion, cell proliferation, differentiation, and motility. PIP5K isoforms possess almost no homology to kinase motifs in other phosphatidylinositol, protein, and lipid kinases. Conserved basic residues may form a dual specificity site for phosphatidylinositol 3- and 5-phosphates. PIP5K2B specifically interacts with the juxtamembrane region of TNFR1; PIP5K2B activity is increased by TNF-alpha. (NCI)

Phosphatidylinositol-4-Phosphate-5-Kinase Type-II Beta Synonyms

Phosphatidylinositol-4-Phosphate 5-Kinase Type II Beta, 1-Phosphatidylinositol-4-Phosphate Kinase, Diphosphoinositide Kinase, PIP5KIIB, PIPKII-Beta, PTDINS(4)P-5-Kinase

Terms in Phosphatidylinositol-4-Phosphate-5-Kinase Type-II Beta category

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